GABAA receptor diversity and pharmacology
نویسندگان
چکیده
منابع مشابه
GABAA receptor pharmacology.
gamma-Aminobutyric acid (GABA)A receptors for the inhibitory neurotransmitter GABA are likely to be found on most, if not all, neurons in the brain and spinal cord. They appear to be the most complicated of the superfamily of ligand-gated ion channels in terms of the large number of receptor subtypes and also the variety of ligands that interact with specific sites on the receptors. There appea...
متن کاملFunction and pharmacology of multiple GABAA receptor subunits.
LYl7l555. SinLe forskolin activates adenylyl cyclase, effects of Dr receptors on Na'/X+-ATPase would then be mediated via protein phosphorylation and CAMP-dependent protein kinase. There are reports that Na+/K+-ATPase may be regulated by phosphoryl-ation, and CAMP has been reported to inhibit the enzyme via a cAMP-&pendent protein kinase7, consistent with the scheme outlined above. However, it ...
متن کاملExtrasynaptic GABAA receptors: form, pharmacology, and function.
GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABA(A) and GABA(B) receptors. Recently, a novel form of GABA(A) receptor-mediated inhibition, termed "tonic" inhibition, has been described. Whereas synaptic GABA(A) receptors underlie classical "phasic" GABA(A) receptor-mediated inhibition (inhibitory postsynaptic currents), tonic GABA(A) receptor-mediated inhibition re...
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Background γ-Aminobutyric acid (GABA) is considered to be the predominant inhibitory neurotransmitter in mammalian central nervous systems (CNS). There are two major classes of GABA receptors: GABAARs and GABABRs. The GABAA receptor is derived from various subunits such as alpha1-alpha 6, beta1-beta 3, gamma1-gamma 4, delta, epsilon, pi, and rho1-3. Intensive research has been performed to und...
متن کاملComparative models of GABAA receptor extracellular and transmembrane domains: important insights in pharmacology and function.
Comparative models of the extracellular and transmembrane domains of GABAA receptors in the agonist-free state were generated based on the recently published structures of the nicotinic acetylcholine receptor. The models were validated by computational methods, and their reliability was estimated by analyzing conserved and variable elements of the cys-loop receptor topology. In addition, the me...
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ژورنال
عنوان ژورنال: Cell and Tissue Research
سال: 2006
ISSN: 0302-766X,1432-0878
DOI: 10.1007/s00441-006-0284-3